Side Effects (in theaters Friday)

When Steven Soderbergh opens the box on a genre, he doesn’t exactly play by the rules. The same director who brought a 1970s European pulse to his revenge thriller Haywire and giddy Billy Wilder-worthy overtones to the true-life whistleblower tale The Informant! is sure to have a trick up his sleeve with Side Effects.

Billed as a crime thriller, the film features The Girl with the Dragon Tattoo star Rooney Mara as a young wife hooked on prescription pills and Jude Law as the doctor who may be criminally complicit in her addiction and an illicit liaison.

As Mara’s first lead role, it is a litmus test for her longevity. Can she break out of the Dragon mold? With this, his last new film in theaters before a self-imposed retirement (his Liberace biopic Behind the Candelabra will arrive on HBO next year), can Soderbergh come full circle and deliver a big message picture that is also hugely entertaining? Watch the trailer below: